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1 "Miyong To Kim"
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Original Article
Impaired fasting glucose, single-nucleotide polymorphisms, and risk for colorectal cancer in Koreans
Keum Ji Jung, Miyong To Kim, Sun Ha Jee
Epidemiol Health. 2016;38:e2016002.   Published online January 6, 2016
DOI: https://doi.org/10.4178/epih.e2016002
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  • 9 Web of Science
  • 8 Crossref
AbstractAbstract AbstractSummary PDF
Abstract
OBJECTIVES
Numerous studies have demonstrated that fasting serum glucose (FSG) levels and certain single-nucleotide polymorphisms (SNPs) are related to an increased risk of colorectal cancer (CRC); however, their combined effects are still unclear.
METHODS
Of a total of 144,527 men and women free of cancer at baseline, 317 developed CRC during 5.3 years of follow-up. A case-cohort study (n=1,691) was used, consisting of participants with a DNA sample available. Three well-known SNPs (rs3802842, rs6983267, rs10795668) were genotyped. Hazard ratios (HR) and 95% confidence intervals (CI) of CRC, colon and rectal cancer were calculated, with the Cox proportional hazard models.
RESULTS
The crude incidence rates per 100,000 person-years were 41.1 overall, 48.4 for men, and 29.3 for women. Among participants with dysglycemia, SNPs rs3802842 and rs6983267 were both associated with an increased risk of CRC (HR, 3.2; 95% CI, 1.9 to 5.5 and HR, 1.8; 95% CI, 1.1 to 3.1, respectively) and rectal cancer (HR, 3.4; 95% CI, 1.8 to 6.6 and HR, 3.3; 95% CI, 1.6 to 7.1, respectively). The interaction effect of dysglycemia and SNPs was positive, that is, resulted in an elevated risk of CRC, but was not statistically significant.
CONCLUSIONS
This study demonstrates that both high FSG and certain SNPs are major risk factors for CRC and rectal cancer but that they did not interact synergistically. The difference in effect size of the SNPs according to CRC subtype (i.e., colon or rectal cancer) and presence of dysglycemia merits further research.
Summary
Korean summary
본 연구에서는 공복혈당농도와 대장암과 관련된 단일염기다형성(SNP)과의 관련성을 살펴 보았다. 높은 공복혈당농도와 단일염기다형성(SNP_rs3802842, rs6983267)은 대장암의 주요한 위험요인이었으나, 두 가지 요인의 상호작용으로 인한 시너지 효과는 없는 것으로 나타났다. 대장암의 아형에 따른 다른 효과 크기와 이상혈당증 유무에 따른 향후 연구가 더 필요할 것으로 생각된다.

Citations

Citations to this article as recorded by  
  • Glycemic traits and colorectal cancer survival in a cohort of South Korean patients: A Mendelian randomization analysis
    So Yon Jun, Sooyoung Cho, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Seung Yong Jeong, Kyu Joo Park, Aesun Shin
    Cancer Medicine.2024;[Epub]     CrossRef
  • The effect of pain-education nursing based on a mind map on postoperative pain score and quality of life in patients with colorectal cancer
    Shan Li, Xiaohong Zhu, Lihua Zhang, Cui Huang, Dan Li
    Medicine.2023; 102(19): e33562.     CrossRef
  • The lncRNA CCAT2 Rs6983267 G Variant Contributes to Increased Sepsis Susceptibility in a Southern Chinese Population
    Zhiyuan Wu, Yufeng Liang, Yunlong Zuo, Yufen Xu, Hanran Mai, Lei Pi, Di Che, Xiaoqiong Gu
    Infection and Drug Resistance.2021; Volume 14: 2969.     CrossRef
  • Distinct Patterns of Interleukin-12/23 and Tumor Necrosis Factor α Synthesis by Activated Macrophages are Modulated by Glucose and Colon Cancer Metabolites
    Ching-Ying Huang, Linda Chia-Hui Yu
    Chinese Journal of Physiology.2020; 63(1): 7.     CrossRef
  • Glucose Metabolites Exert Opposing Roles in Tumor Chemoresistance
    Chung-Yen Huang, Ching-Ying Huang, Yu-Chen Pai, Been-Ren Lin, Tsung-Chun Lee, Pi-Hui Liang, Linda Chia-Hui Yu
    Frontiers in Oncology.2019;[Epub]     CrossRef
  • Association among genetic variants in the vitamin D pathway and circulating 25-hydroxyvitamin D levels in Korean adults: results from the Korea National Health and Nutrition Examination Survey 2011–2012
    So-Young Kwak, Clara Yongjoo Park, Garam Jo, Oh Yoen Kim, Min-Jeong Shin
    Endocrine Journal.2018; 65(9): 881.     CrossRef
  • Body mass index and incidence of thyroid cancer in Korea: the Korean Cancer Prevention Study-II
    Hyun-Young Shin, Yong Ho Jee, Eo Rin Cho
    Journal of Cancer Research and Clinical Oncology.2017; 143(1): 143.     CrossRef
  • Heart Rate Recovery and Cancer Risk: Prospective Cohort Study
    Yong Hyun Byun, Sang Yeun Kim, Yejin Mok, Youngwon Kim, Sun Ha Jee
    Asia Pacific Journal of Public Health.2017; : 101053951774563.     CrossRef
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